Description

Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, 7,7-Difluoro-, Methyl Ester is a high-purity, advanced fluorinated building block characterized by its strained bicyclic structure. This compound is valued for its unique reactivity profile, enabling the synthesis of complex molecules with enhanced physicochemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated, strained-ring scaffolds in drug discovery, particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the difluorocyclopropane moiety can improve metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the rigid, fluorinated structure can influence material properties.
• Fluorine Chemistry: An important reagent for studying cyclopropanation reactions and the effects of gem-difluoro substitution on ring strain and reactivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, 7,7-Difluoro-, Methyl Ester
CAS No.	1494594-75-0
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	7,7-Difluorobicyclo[4.1.0]heptane-3-carboxylic acid methyl ester; Methyl 7,7-difluorobicyclo[4.1.0]heptane-3-carboxylate; 7,7-Difluoro-3-carbomethoxybicyclo[4.1.0]heptane; Methyl 7,7-difluoro-3-norcarenecarboxylate; Difluorinated norcarane methyl ester
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, 7,7-Difluoro-, Methyl Ester is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) including HPLC purity, NMR, and MS data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.