Description

tert-Butyl 3-Cyano-3-Hydroxyazetidine-1-Carboxylate is a high-value azetidine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both cyano and hydroxyl functional groups on a strained four-membered ring, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, particularly in protease inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its azetidine scaffold for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of novel polymers and functional materials with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	tert-Butyl 3-Cyano-3-Hydroxyazetidine-1-Carboxylate
CAS No.	1493737-08-8
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	1-Boc-3-Cyano-3-hydroxyazetidine; 3-Hydroxy-3-cyanoazetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-cyano-3-hydroxy-1-azetidinecarboxylate; 1-(tert-Butoxycarbonyl)-3-cyano-3-azetidinol; 3-Cyano-3-hydroxyazetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-cyano-3-hydroxy-, 1,1-dimethylethyl ester; Boc-3-Cyano-3-hydroxyazetidine
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 3-Cyano-3-Hydroxyazetidine-1-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are supported by comprehensive Certificates of Analysis (COA) detailing all critical parameters. We adhere to cGMP principles where applicable to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.