Description

4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block. This compound is specifically engineered for advanced organic synthesis, offering a unique combination of bromo, fluoro, and trifluoroethoxy substituents for precise molecular modification. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial precursor for novel herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of advanced functional materials for electronic displays and lighting, where the trifluoroethoxy group can influence dielectric and luminescent properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions to construct complex biaryl and heteroaryl structures.
• Fluorine Chemistry Exploration: An important reagent for studying structure-activity relationships (SAR) in medicinal chemistry due to its distinct fluorine substitution pattern.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	1492025-34-9
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	1-Bromo-4-fluoro-2-(2,2,2-trifluoroethoxy)benzene; 2-Bromo-5-fluoro-1-(2,2,2-trifluoroethoxy)benzene; 4-Bromo-1-fluoro-2-(trifluoroethoxy)benzene; 2-(2,2,2-Trifluoroethoxy)-4-bromo-1-fluorobenzene; Benzene, 4-bromo-1-fluoro-2-(2,2,2-trifluoroethoxy)-; 1492025-34-9
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.