Description

(2R)-6-[(4S)-5-(tert-Butoxy)-4-Hexadecanamido-5-Oxopentanamido]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Hexanoic Acid is a sophisticated, high-purity synthetic building block designed for advanced research and development. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutic agents, including peptide-based drugs and targeted biologics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the solid-phase and solution-phase synthesis of complex peptide drug candidates.
• Peptidomimetic Research: Used to incorporate specific, protected amino acid sequences into novel non-peptide structures that mimic bioactive peptides.
• Bioconjugation: Serves as a specialized linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Protecting Group Strategy: The Fmoc (9-fluorenylmethoxycarbonyl) protecting group makes it essential for standard Fmoc-based peptide synthesis protocols.
• Chemical Biology Probes: Employed in the creation of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Development: Used in scaling up and optimizing synthetic routes for GMP (Good Manufacturing Practice) production of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2R)-6-[(4S)-5-(tert-Butoxy)-4-Hexadecanamido-5-Oxopentanamido]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Hexanoic Acid
CAS No.	1491158-71-4
Molecular Formula	C47H69N3O8
Molecular Weight	804.07 g/mol
Synonyms	Fmoc-Lys(Palmitoyl-Glu(OtBu))-OH; N6-(Palmitoyl-L-γ-glutamyl)-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine; Fmoc-Lys(Pal-Glu(OtBu))-OH; Palmitoyl-γ-Glu(OtBu)-Lys(Fmoc); Lipopeptide Building Block; CAS 1491158-71-4; N2-Fmoc-N6-(N-palmitoyl-L-γ-glutamyl)-L-lysine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and pre-clinical development. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and analytical data. Our quality systems support traceability and consistency, meeting the exacting standards required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.