Description

T-Butyl-4'-(Trifluoromethyl)Benzoate-2'-Boronic Acid is a high-purity, multi-functional organoboron building block essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethyl and benzoate motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the boronic acid group facilitates efficient coupling.
• Material Science Research: Employed in the creation of advanced organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: Serves as a critical coupling partner (boronic acid reagent) for forming biaryl and other C-C bonds in complex molecule assembly.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Process Chemistry & Scale-Up: Suitable for route scouting and optimization from milligram to kilogram scale in process R&D.

Basic Information

Item	Details
Product Name	T-Butyl-4'-(Trifluoromethyl)Benzoate-2'-Boronic Acid
CAS No.	1489293-05-1
Molecular Formula	C12H14BF3O4
Molecular Weight	290.05 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-5-(trifluoromethyl)phenylboronic acid; 2-Borono-5-(trifluoromethyl)benzoic acid tert-butyl ester; tert-Butyl 2-borono-5-(trifluoromethyl)benzoate; 4-(tert-Butoxycarbonyl)-2-(trifluoromethyl)phenylboronic acid; [2-(tert-Butoxycarbonyl)-5-(trifluoromethyl)phenyl]boronic acid; T-Butyl 4-(Trifluoromethyl)benzoate-2-boronic Acid; 2-Boronoterephthalic acid 1-tert-butyl ester 4-trifluoromethyl derivative
EINECS	Contact for details

Quality Control

Our T-Butyl-4'-(Trifluoromethyl)Benzoate-2'-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.