Description

n-Fmoc-n-(2,2,2-Trifluoroethyl)Glycine CAS NO 1486953-68-7 is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound matters because it introduces a trifluoroethyl side chain, a key modification that enhances metabolic stability and alters the physicochemical properties of target peptides. Pharmaceutical researchers and peptide chemists need it for developing novel therapeutic peptides, peptidomimetics, and as a crucial building block in solid-phase peptide synthesis (SPPS) for drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used to incorporate the 2,2,2-trifluoroethyl moiety into peptide backbones to improve drug-like properties such as metabolic stability and lipophilicity.
• Peptidomimetic Design: Serves as a key intermediate in creating non-natural peptide analogs for probing biological function and enhancing therapeutic efficacy.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• API Intermediate Manufacturing: Acts as a high-purity starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.

Basic Information

Product Name	n-Fmoc-n-(2,2,2-Trifluoroethyl)Glycine
CAS No.	1486953-68-7
Molecular Formula	C₂₁H₂₀F₃NO₄
Molecular Weight	407.38 g/mol
Synonyms	Fmoc-N-(2,2,2-Trifluoroethyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(2,2,2-trifluoroethyl)glycine; (2-(((9H-Fluoren-9-yl)methoxy)carbonyl)(2,2,2-trifluoroethyl)amino)acetic acid; Fmoc-Tfe-Gly-OH; N-Fmoc-N-(2,2,2-trifluoroethyl)glycine; N-(2,2,2-Trifluoroethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine; Fmoc-N-(Tfe)Gly-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-(2,2,2-Trifluoroethyl)Glycine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.