Description

1-{[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a pyrrolidine moiety and a protected boronic ester functional group. This compound is critically important for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile coupling partner to introduce fluorinated aryl fragments into complex molecular architectures.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science & OLED Development: Serves as a precursor for creating novel organic electronic materials and emissive layers.
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules to study biological pathways.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in research laboratories worldwide.

Basic Information

Product Name	1-{[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine
CAS No.	1486485-42-0
Molecular Formula	C17H25BFNO2
Molecular Weight	305.20 g/mol
Synonyms	1-[(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]pyrrolidine; 2-[2-Fluoro-5-(pyrrolidin-1-ylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl pyrrolidine-1-carboxylate (common error name); (4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine derivative; Fluorinated phenylpyrrolidine boronic ester; Borofluoropyrrolidine intermediate; CAS 1486485-42-0.
EINECS	Contact for details

Quality Control

Every batch of 1-{[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.