Description

Belinostat Glucuronide is a key metabolite of the histone deacetylase (HDAC) inhibitor Belinostat. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories engaged in oncology drug development and clinical studies. Researchers and quality control units in pharmaceutical, biotechnology, and contract research organizations require this high-purity compound to ensure accurate analytical results.

Application

• Pharmacokinetic and Metabolism Studies: Used as a certified reference standard to quantify Belinostat metabolites in biological matrices.
• Bioanalytical Method Development: Essential for developing and validating HPLC, LC-MS, and LC-MS/MS assays in support of clinical trials.
• Drug Impurity Profiling: Acts as a known impurity or degradation product standard for the quality control of Belinostat API and finished drug products.
• Preclinical and Clinical Research: Supports investigative studies on the efficacy, safety, and metabolic pathways of HDAC inhibitor therapies.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite identification and quantification.

Basic Information

Product Name	Belinostat Glucuronide
CAS No.	1486471-13-9
Molecular Formula	C₂₃H₂₈N₄O₁₂
Molecular Weight	552.49 g/mol
Synonyms	PXD101 Glucuronide; N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide Glucuronide; Belinostat O-Glucuronide; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[[(2E)-3-[3-[(phenylamino)sulfonyl]phenyl]prop-2-enoyl]amino]oxane-2-carboxylic Acid; PXD-101 Metabolite
EINECS	Contact for details

Quality Control

Our Belinostat Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical reference standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research and quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.