Description

n-Acetyl-L-Alanine-3,3,3-D3 is a deuterated derivative of the amino acid alanine, specifically labeled on the methyl group of the side chain. This stable isotope-labeled compound is essential for advanced research and development, providing a non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is a critical material for scientists in pharmaceutical R&D, analytical chemistry, and life sciences who require high-purity, isotopically labeled building blocks for mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical method development for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer to investigate amino acid metabolism, protein synthesis, and related biochemical pathways in vivo and in vitro.
• Pharmaceutical Impurity Profiling: Employed in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Proteomics and Biomarker Research: Facilitates accurate relative and absolute quantification in peptide and protein analysis using mass spectrometry-based techniques.
• Synthesis of Labeled Peptides: Acts as a protected, isotopically labeled amino acid precursor for the solid-phase or solution-phase synthesis of deuterated peptides.
• NMR Spectroscopy: Provides a useful tool for mechanistic studies and structural analysis due to the distinct spectroscopic signature of deuterium.

Basic Information

Product Name	n-Acetyl-L-Alanine-3,3,3-D3
CAS No.	1485548-36-4
Molecular Formula	C5H6D3NO3
Molecular Weight	135.15 g/mol
Synonyms	(2S)-2-Acetamidopropanoic-3,3,3-d3 Acid; N-Acetyl-L-alanine-d3; L-Alanine, N-acetyl-, 3,3,3-d3; Ac-Ala-d3-OH; N-Acetylalanine-d3; Deuterated N-Acetyl-L-alanine; 2-Acetamidopropionic-3,3,3-d3 Acid
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Alanine-3,3,3-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS or NMR), and chiral purity. We adhere to cGMP principles for research-grade materials, and specifications can be aligned with client requirements for specific projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.