Description

trans-4-(Trifluoromethyl)-Cyclohexanemethanamine is a high-value, chiral amine building block characterized by its rigid cyclohexane backbone and a strategically positioned trifluoromethyl group. This compound matters for its unique combination of structural rigidity and the electronic properties imparted by the fluorine atoms, making it a critical intermediate in advanced synthetic chemistry. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where it serves as a key scaffold to modulate bioavailability, metabolic stability, and target binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the CF₃ group enhances lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into specialty polymers and advanced organic frameworks to impart specific chemical and physical properties.
• Fluorinated Compound Library: An essential building block for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	trans-4-(Trifluoromethyl)-Cyclohexanemethanamine
CAS No.	1469976-96-2
Molecular Formula	C₈H₁₄F₃N
Molecular Weight	181.20 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexanemethylamine; (trans-4-(Trifluoromethyl)cyclohexyl)methanamine; 4-(Trifluoromethyl)cyclohexanemethanamine (trans-); 1-[trans-4-(Trifluoromethyl)cyclohexyl]methanamine; 4-(Trifluoromethyl)cyclohexanemethylamine, trans-; (1r,4r)-4-(Trifluoromethyl)cyclohexanemethanamine; (trans)-4-(Trifluoromethyl)cyclohexanemethanamine
EINECS	Contact for details

Quality Control

Our trans-4-(Trifluoromethyl)-Cyclohexanemethanamine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided to guarantee supply reliability and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This amine is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.