Description

Digoxin-4’’’-o-Tetra-o-Acetyl β-D-Glucopyranoside is a key acetylated glycoside derivative of the cardiac glycoside digoxin. This compound serves as a critical intermediate in the synthesis of novel cardiac agents and for biochemical research into glycoside structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on cardiovascular drug discovery and glycoscience.

Application

• Pharmaceutical Intermediate: A vital precursor in the research and development of novel digoxin analogs and prodrugs with potentially improved pharmacokinetic profiles.
• Biochemical Research: Used as a standard or reagent in studies investigating the impact of glycosylation on the biological activity and receptor binding of cardiac glycosides.
• Metabolic Pathway Studies: Employed in research to trace and understand the metabolic pathways and biotransformation of digoxin and related compounds.
• Reference Standard: Serves as a high-purity analytical reference standard for quality control and method development in pharmaceutical analysis.
• Chemical Synthesis: Utilized in organic synthesis for the selective deprotection of acetyl groups to study different glycosylation patterns.

Basic Information

Product Name	Digoxin-4’’’-o-Tetra-o-Acetyl β-D-Glucopyranoside
CAS No.	1469804-92-9
Molecular Formula	C53H82O22
Molecular Weight	1047.20 g/mol
Synonyms	Digoxin 4'''-O-tetraacetyl-β-D-glucopyranoside; 4'''-O-(Tetra-O-acetyl-β-D-glucopyranosyl)digoxin; Digoxin tetraacetyl glucoside; Digoxin-4'''-O-tetraacetylglucoside; β-D-Glucopyranoside, 4'''-O-(tetra-O-acetyl-β-D-glucopyranosyl)digoxin; Cardiac glycoside acetylated intermediate
EINECS	Contact for details

Quality Control

Our Digoxin-4’’’-o-Tetra-o-Acetyl β-D-Glucopyranoside is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets rigorous research-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.