Description

2-(Azetidin-3-Yl)-2-Methylpropanenitrile Tfa is a high-purity, specialized nitrile building block containing an azetidine ring system. This compound is a critical intermediate in modern pharmaceutical research and development, enabling the synthesis of novel bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures, particularly in the search for new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique azetidine scaffold.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors targeting various proteolytic enzymes.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and target validation.
• Peptidomimetics: Incorporated into peptide-like structures to enhance metabolic stability and bioavailability.
• Agrochemical Research: Potential intermediate in the discovery of new active ingredients for crop protection.

Basic Information

Product Name	2-(Azetidin-3-Yl)-2-Methylpropanenitrile Tfa
CAS No.	1466514-83-9
Molecular Formula	C9H13F3N2O2
Molecular Weight	238.21 g/mol
Synonyms	2-(Azetidin-3-yl)-2-methylpropanenitrile trifluoroacetate; 2-Methyl-2-(azetidin-3-yl)propanenitrile trifluoroacetic acid salt; 3-(2-Cyano-2-propyl)azetidine trifluoroacetate; 2-(Azetidin-3-yl)-2-methylpropionitrile TFA; Azetidine-3-carbonitrile, 2,2-dimethyl-, trifluoroacetate; 1466514-83-9; TFA salt of 2-(azetidin-3-yl)-2-methylpropanenitrile
EINECS	Contact for details

Quality Control

Our 2-(Azetidin-3-Yl)-2-Methylpropanenitrile Tfa is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.