Description

1-Pyrrolidinecarboxylic Acid, 2-(Fluoromethyl)-, 1,1-Dimethylethyl Ester, (2R)- is a high-value, chiral building block and advanced pharmaceutical intermediate of significant importance in modern organic synthesis. Its core value lies in its unique molecular architecture, featuring a fluoromethyl substituent and a protected carboxylic acid group, which enables the precise construction of complex bioactive molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated fluorine chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Peptidomimetics & Prodrug Design: Serves as a key component for constructing peptidomimetic scaffolds and designing prodrugs with improved pharmacokinetic properties.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers with high enantiomeric purity.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in organofluorine chemistry.
• Material Science: Potential use in the synthesis of specialized fluorinated polymers or ligands for catalytic systems.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 2-(Fluoromethyl)-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	1464137-21-0
Molecular Formula	C10H18FNO2
Molecular Weight	203.26 g/mol
Synonyms	(2R)-2-(Fluoromethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (2R)-2-(fluoromethyl)pyrrolidine-1-carboxylate; (R)-tert-Butyl 2-(fluoromethyl)pyrrolidine-1-carboxylate; (R)-N-Boc-2-(fluoromethyl)pyrrolidine; Boc-(R)-2-(fluoromethyl)pyrrolidine; (R)-2-(Fluoromethyl)-1-(tert-butoxycarbonyl)pyrrolidine; 1-Pyrrolidinecarboxylic acid, 2-(fluoromethyl)-, 1,1-dimethylethyl ester, (2R)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.