Description

tert-Butyl 3-(Prop-2-Yn-1-Yl)Azetidine-1-Carboxylate is a high-purity, protected azetidine derivative featuring a terminal alkyne functional group, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in enabling efficient, modular construction of complex molecular architectures through robust coupling reactions like the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly for creating novel heterocyclic scaffolds and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel azetidine-containing drug candidates, leveraging the alkyne handle for "click chemistry" bioconjugation.
• Agrochemical Research: Used in the design and development of new pesticides and herbicides, where the azetidine ring can impart unique biological activity.
• Chemical Biology Probe Development: Serves as a precursor for labeling reagents and activity-based probes, enabling the study of biological processes.
• Material Science: Employed in the synthesis of functional polymers and dendrimers with tailored properties via polymerization or post-polymerization modification.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries through parallel and combinatorial chemistry approaches.
• Ligand and Catalyst Development: Acts as a building block for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	tert-Butyl 3-(Prop-2-Yn-1-Yl)Azetidine-1-Carboxylate
CAS No.	1463502-41-1
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	1-Boc-3-(2-propynyl)azetidine; tert-Butyl 3-(2-propynyl)azetidine-1-carboxylate; 3-(Prop-2-yn-1-yl)azetidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(2-propynyl)azetidine; Boc-3-(prop-2-yn-1-yl)azetidine; Azetidine-1-carboxylic acid, 3-(2-propynyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 3-(Prop-2-Yn-1-Yl)Azetidine-1-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity, typically meeting standards suitable for research and process development. Our commitment to quality ensures reliable performance in sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.