Description

tert-Butyl n-[(1S,3S)-3-Ethynylcyclobutyl]Carbamate is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including potential kinase inhibitors and other small molecule drugs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for the design of peptide-like molecules with enhanced metabolic stability.
• Chemical Biology Probes: The ethynyl group enables further functionalization via click chemistry (e.g., CuAAC) for labeling and bioconjugation applications.
• Agrochemical Research: Employed in the synthesis of novel, biologically active compounds for crop protection.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block to induce stereoselectivity in complex multi-step synthetic routes.

Basic Information

Product Name	tert-Butyl n-[(1S,3S)-3-Ethynylcyclobutyl]Carbamate
CAS No.	1463502-31-9
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	(1S,3S)-3-Ethynylcyclobutylcarbamic acid tert-butyl ester; tert-Butyl (1S,3S)-3-ethynylcyclobutylcarbamate; (1S,3S)-N-Boc-3-ethynylcyclobutanamine; Boc-(1S,3S)-3-ethynylcyclobutanamine; (1S,3S)-3-Ethynyl-1-((tert-butoxycarbonyl)amino)cyclobutane; (1S,3S)-3-Ethynylcyclobutanamine N-Boc protected; BOC-(1S,3S)-3-Ethynylcyclobutanamine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(1S,3S)-3-Ethynylcyclobutyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.