Description

2,2-Difluorocyclohexane-1-Carboxylic Acid is a high-value fluorinated building block characterized by its unique cyclohexane ring structure with two fluorine atoms and a carboxylic acid functional group. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorocyclohexyl moiety can enhance product efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with tailored surface properties and chemical resistance.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination reactions and the stereoelectronic effects of gem-difluoro groups in alicyclic systems.

Basic Information

Product Name	2,2-Difluorocyclohexane-1-Carboxylic Acid
CAS No.	1461714-25-9
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	2,2-Difluorocyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 2,2-difluoro-; 2,2-Difluoro-1-cyclohexanecarboxylic acid; 2,2-Difluorocyclohexane Carboxylic Acid; 1-Carboxy-2,2-difluorocyclohexane; 2,2-Difluorocyclohexyl-1-carboxylic Acid; 1461714-25-9
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of heat. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.