Description

(1-Cyanocyclopropyl)Methanesulfonyl Chloride is a specialized sulfonyl chloride derivative featuring a reactive nitrile group on a strained cyclopropyl ring. This unique bifunctional structure makes it a valuable high-purity building block for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research chemists and process development scientists in pharmaceutical, agrochemical, and fine chemical industries who require precise and reliable intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with unique modes of action.
• Chemical Biology Probe Development: Serves as a reactive handle for creating activity-based probes (ABPs) to study enzyme function and target engagement.
• Peptidomimetic & Macrocycle Synthesis: The reactive sulfonyl chloride group is utilized for sulfonamide bond formation in constructing constrained peptides and cyclic compounds.
• Material Science Research: Potential monomer or cross-linking agent for developing specialty polymers with specific thermal or chemical resistance properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this niche intermediate.

Basic Information

Item	Details
Product Name	(1-Cyanocyclopropyl)Methanesulfonyl Chloride
CAS No.	1461707-09-4
Molecular Formula	C5H6ClNO2S
Molecular Weight	179.62 g/mol
Synonyms	1-Cyanocyclopropane-1-sulfonyl chloride; (1-Cyano-1-cyclopropyl)methanesulfonyl chloride; Cyclopropanecarbonitrile, 1-(chlorosulfonyl)-; 1-(Chlorosulfonyl)cyclopropanecarbonitrile; (Cyanocyclopropyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (1-Cyanocyclopropyl)Methanesulfonyl Chloride is produced and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and compliance with your internal specifications. Our commitment to cGMP (current Good Manufacturing Practice) standards for advanced intermediates guarantees the consistency and reliability required for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.