Description

(R)-Benzyl (1-((2,2-Dimethoxyethyl)Amino)-3-Methyl-1-Oxobutan-2-Yl)Carbamate is a high-purity chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex, biologically active molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those working on peptide mimetics, protease inhibitors, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting metabolic and neurological disorders.
• Peptidomimetic Research: Serves as a backbone component for designing and synthesizing non-natural peptide analogs with enhanced stability and bioavailability.
• Protease Inhibitor Development: Used in the construction of selective inhibitor scaffolds for enzymes like renin, HIV protease, and thrombin.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce defined stereocenters.
• Chemical Biology & Probe Synthesis: Utilized for creating labeled or modified peptide fragments to study protein-protein interactions and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(R)-Benzyl (1-((2,2-Dimethoxyethyl)Amino)-3-Methyl-1-Oxobutan-2-Yl)Carbamate
CAS No.	1456693-00-7
Molecular Formula	C18H28N2O5
Molecular Weight	352.43 g/mol
Synonyms	Carbamic acid, N-[(1R)-1-[[(2,2-dimethoxyethyl)amino]carbonyl]-2-methylpropyl]-, phenylmethyl ester; (R)-Benzyl N-((2,2-dimethoxyethyl)carbamoyl)-L-valinate; Benzyl (R)-1-((2,2-dimethoxyethyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate; (R)-Benzyl 1-((2,2-dimethoxyethyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate; (2R)-3-Methyl-2-({[(phenylmethoxy)carbonyl]amino}methyl)butanoic acid 2,2-dimethoxyethylamide; Protected Dmav-OH derivative; Chiral Valine derivative with Cbz and acetal-protected amine.
EINECS	Contact for details

Quality Control

Our (R)-Benzyl (1-((2,2-Dimethoxyethyl)Amino)-3-Methyl-1-Oxobutan-2-Yl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.