Description

4-Chloro-2-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block essential for modern cross-coupling reactions. Its primary value lies in enabling the efficient and selective construction of complex, multi-substituted aromatic frameworks, which are critical scaffolds in advanced material and pharmaceutical research. This compound is specifically designed for use by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating novel fluorinated and chlorinated aromatic compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the specific halogen substitution pattern can influence bioactivity and environmental stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors), where precise molecular architecture is crucial.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and other advanced synthetic methodologies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes, leveraging the boronic ester's potential for further functionalization.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	1454914-16-9
Molecular Formula	C13H17BClFO2
Molecular Weight	270.54 g/mol
Synonyms	4-Chloro-2-fluoro-3-methylbenzeneboronic acid pinacol ester; (4-Chloro-2-fluoro-3-methylphenyl)boronic acid pinacol ester; 2-(4-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-2-fluoro-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; Pinacol (4-Chloro-2-fluoro-3-methylphenyl)boronate; Boronic acid, B-(4-chloro-2-fluoro-3-methylphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 1454914-16-9
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management protocols and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent in-house specifications, with purity typically verified by NMR (¹H, ¹³C, ¹¹B) and HPLC analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.