Description

2-Fluoro-4-(4-Methyl-1-Piperazinylcarbonyl)Benzeneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials. Its unique structure, combining a boronic acid group with a fluorinated aromatic ring and a piperazine carbonyl moiety, makes it a versatile intermediate for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic acid partner for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Material Science: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Utilized as a molecular probe or linker in the study of protein interactions and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Fluoro-4-(4-Methyl-1-Piperazinylcarbonyl)Benzeneboronic Acid
CAS No.	1454901-23-5
Molecular Formula	C13H18BFN2O3
Molecular Weight	280.11 g/mol
Synonyms	2-Fluoro-4-[(4-methylpiperazin-1-yl)carbonyl]benzeneboronic Acid; [2-Fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl]boronic Acid; 4-Borono-3-fluoro-N-(4-methylpiperazin-1-yl)benzamide; 2-Fluoro-4-(4-methylpiperazine-1-carbonyl)phenylboronic Acid; B-[2-Fluoro-4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]boronic Acid; 1454901-23-5; 2-Fluoro-4-(4-methylpiperazin-1-yl)carbonylphenylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(4-Methyl-1-Piperazinylcarbonyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.