Description

n-Fmoc-3-(2-Propyn-1-Yloxy)-L-Phenylalanine is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and chemical biology research. This compound is engineered to introduce a propargyl ether-protected phenolic side chain, enabling highly selective bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and bioconjugation who require precise site-specific labeling of peptides and proteins.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the controlled incorporation of a clickable handle into synthetic peptide chains.
• Site-Specific Bioconjugation: Enables the covalent attachment of fluorophores, PEG chains, drugs, or other functional moieties to peptides and proteins via copper-catalyzed click reactions.
• Chemical Probe Development: Used to create activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.
• Peptidomimetic & Drug Discovery: Serves as a building block for designing novel peptide-based therapeutics and diagnostic agents with enhanced stability and targeting capabilities.
• Material Science: Facilitates the functionalization of surfaces and polymers with bioactive peptides for applications in biosensors and biomaterials.
• Antibody-Drug Conjugate (ADC) Research: Provides a controlled method for linking cytotoxic payloads to antibodies or antibody fragments.

Basic Information

Product Name	n-Fmoc-3-(2-Propyn-1-Yloxy)-L-Phenylalanine
CAS No.	1454817-57-2
Molecular Formula	C₂₇H₂₃NO₅
Molecular Weight	441.48 g/mol
Synonyms	Fmoc-3-O-propargyl-L-tyrosine; Fmoc-Tyr(3-O-propargyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-propyn-1-yloxy)-L-phenylalanine; Fmoc-L-Tyr(3-O-propargyl); 3-(Prop-2-yn-1-yloxy)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine; Fmoc-3-O-propargyltyrosine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[3-(prop-2-yn-1-yloxy)phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-(2-Propyn-1-Yloxy)-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.