Description

(S)-[2’-(2-Naphthylmethyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine is a highly valuable, chiral monophosphine ligand designed for asymmetric catalysis. Its sophisticated binaphthyl-based scaffold provides exceptional steric and electronic tuning, enabling superior enantioselectivity and catalytic activity in critical bond-forming reactions. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop efficient and sustainable synthetic routes for high-value chiral intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical API synthesis.
• Asymmetric Cross-Coupling: Facilitates C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, with high enantiocontrol.
• Asymmetric Allylic Substitution: Used to create chiral centers via Tsuji-Trost and related reactions for building complex molecular architectures.
• Hydrosilylation & Hydroboration: Enables the enantioselective addition of Si-H or B-H bonds to unsaturated substrates.
• Catalyst Screening Libraries: A critical component in high-throughput screening for discovering new chiral catalysts.
• Process Chemistry Optimization: Employed to improve the yield, selectivity, and scalability of existing asymmetric synthetic processes.

Basic Information

Product Name	(S)-[2’-(2-Naphthylmethyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine
CAS No.	1454319-50-6
Molecular Formula	C49H35P
Molecular Weight	654.78 g/mol
Synonyms	(S)-2'-(2-Naphthylmethyl)-[1,1'-binaphthalene]-2-yldiphenylphosphine; (S)-2'-(Naphthalen-2-ylmethyl)-[1,1'-binaphthalene]-2-yldiphenylphosphine; (S)-MOP-NAP; (S)-2-(Diphenylphosphino)-2'-(2-naphthylmethyl)-1,1'-binaphthyl; (S)-2-(2-Naphthylmethyl)-2'-(diphenylphosphino)-1,1'-binaphthyl; (S)-Binaphthyl-Diphenylphosphine Derivative; (S)-NAP-MOP Ligand; (S)-NAP-Phos
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet the stringent requirements of catalysis research and development. Standard quality protocols include HPLC for chiral purity, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.