Description

(S)-[2’-(4-Methylbenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine is a chiral monophosphine ligand belonging to the binaphthyl phosphine family, prized for its high steric bulk and electron-donating properties. Its value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer active pharmaceutical ingredients and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in catalytic reactions such as cross-couplings, hydrogenations, and C-H functionalizations.

Application

• Asymmetric Catalysis: A key chiral ligand for transition metal-catalyzed reactions, including asymmetric hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure intermediates for active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Manufacturing: Applied in the synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Material Science: Potential use in the development of chiral polymers or as a component in advanced catalytic systems.

Basic Information

Product Name	(S)-[2’-(4-Methylbenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine
CAS No.	1454319-49-3
Molecular Formula	C41H31P
Molecular Weight	554.66 g/mol
Synonyms	(S)-2'-(4-Methylbenzyl)-2-(diphenylphosphino)-1,1'-binaphthyl; (S)-2'-(p-Methylbenzyl)-2-(diphenylphosphino)-1,1'-binaphthyl; (S)-[2'-(4-Methylbenzyl)-[1,1'-Binaphthalen]-2-yl]diphenylphosphine; (S)-p-Methylbenzyl-BINAP; (S)-Me-BINAP derivative; (S)-4-Methylbenzyl-substituted BINAP ligand; (S)-2-(Diphenylphosphino)-2'-(4-methylbenzyl)-1,1'-binaphthyl
EINECS	Contact for details

Quality Control

Our (S)-[2’-(4-Methylbenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes rigorous analytical testing, including chiral HPLC, 31P NMR, and 1H NMR, to confirm identity, enantiomeric excess, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for production where required, ensuring suitability for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain purity and catalytic activity. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.