Description

(S)-[2’-(2-Methoxybenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine is a high-value, chiral monophosphine ligand essential for asymmetric catalysis. Its unique steric and electronic properties enable superior enantioselectivity and catalytic activity in critical bond-forming reactions. This compound is a key reagent for R&D chemists and process engineers in the pharmaceutical and fine chemical industries seeking to develop efficient, stereoselective synthetic routes.

Application

• Asymmetric Hydrogenation: A highly effective ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral pharmaceutical intermediates.
• Cross-Coupling Reactions: Facilitates challenging asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions to construct C-C and C-N bonds with high enantiomeric excess.
• Asymmetric Allylic Substitution: Used in Tsuji-Trost and related reactions to install chiral centers with excellent regio- and stereocontrol.
• Hydrosilylation & Hydroboration: Employed in the enantioselective addition of Si-H and B-H bonds to unsaturated substrates for the synthesis of chiral organosilicon and organoboron compounds.
• Pharmaceutical Intermediate Synthesis: Critical for the development of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, such as antiviral, anticancer, and cardiovascular drugs.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.

Basic Information

Product Name	(S)-[2’-(2-Methoxybenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine
CAS No.	1454319-48-2
Molecular Formula	C46H35OP
Molecular Weight	634.75 g/mol
Synonyms	(S)-MOP-BINAP; (S)-2'-(2-Methoxybenzyl)-2-diphenylphosphino-1,1'-binaphthyl; (S)-2-(Diphenylphosphino)-2'-(2-methoxybenzyl)-1,1'-binaphthyl; (S)-Methoxybenzyl-BINAP; (S)-MOP-BINAP Ligand; (S)-Methoxybenzyl-SEGPHOS (related class); (S)-[2'-(2-Methoxybenzyl)-1,1'-binaphthalen]-2-yl-diphenylphosphine; (S)-MOP-BINAP Phosphine Ligand
EINECS	Contact for details

Quality Control

Our production of (S)-[2’-(2-Methoxybenzyl)-[1,1’-Binaphthalen]-2-Yl]Diphenylphosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.