Description

2-Fluoro-3-Bromo-5-Carboxyphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring halogen substituents and a carboxylic acid group, makes it an indispensable reagent for constructing complex molecular architectures, particularly in pharmaceutical and materials science research. This compound is primarily sought after by R&D chemists and process development scientists working on the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core for bioactivity.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organoboron chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized to create boronic acid-based sensors and probes for detecting sugars, peroxides, and other biologically relevant analytes.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-Fluoro-3-Bromo-5-Carboxyphenylboronic Acid
CAS No.	1452575-84-6
Molecular Formula	C7H5BBrFO4
Molecular Weight	261.83 g/mol
Synonyms	(3-Bromo-2-fluoro-5-carboxyphenyl)boronic acid; 5-Borono-3-bromo-2-fluorobenzoic acid; 2-Fluoro-3-bromo-5-carboxybenzeneboronic acid; Benzoic acid, 3-bromo-2-fluoro-5-borono-; B-(3-Bromo-2-fluoro-5-carboxyphenyl)boronic acid; 1452575-84-6; 3-Bromo-2-fluoro-5-carboxy phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Bromo-5-Carboxyphenylboronic Acid is manufactured and tested under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.