Description

5-Bromo-2-Chloro-4-(Trifluoromethyl)Phenylboronicacid is a high-value, multi-functional boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its unique halogenated and trifluoromethylated aromatic structure makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors, where it is used to introduce specific functional groups that modulate the biological activity, metabolic stability, and physical properties of target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides, where the halogen and trifluoromethyl groups enhance efficacy and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Bromo-2-Chloro-4-(Trifluoromethyl)Phenylboronicacid
CAS No.	1452574-71-8
Molecular Formula	C7H4BBrClF3O2
Molecular Weight	303.27 g/mol
Synonyms	[5-Bromo-2-chloro-4-(trifluoromethyl)phenyl]boronic acid; (5-Bromo-2-chloro-4-(trifluoromethyl)phenyl)boronic acid; 5-Bromo-2-chloro-α,α,α-trifluoro-p-tolylboronic acid; 2-Chloro-5-bromo-4-(trifluoromethyl)benzeneboronic acid; Boronic acid, B-[5-bromo-2-chloro-4-(trifluoromethyl)phenyl]-; 1452574-71-8; 5-Br-2-Cl-4-CF3-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-4-(Trifluoromethyl)Phenylboronicacid is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.