Description

2,5-Difluoro-4-Benzyloxyphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, serving as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing difluorinated biphenyl motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Building block for organic electronic materials, such as those used in OLEDs and semiconductors, where fluorine substitution tunes electronic properties.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed research and scale-up projects.

Basic Information

Product Name	2,5-Difluoro-4-Benzyloxyphenylboronic Acid
CAS No.	1452574-01-4
Molecular Formula	C₁₃H₁₁BF₂O₃
Molecular Weight	264.03 g/mol
Synonyms	4-(Benzyloxy)-2,5-difluorophenylboronic Acid; (4-(Benzyloxy)-2,5-difluorophenyl)boronic Acid; 2,5-Difluoro-4-(phenylmethoxy)benzeneboronic Acid; B-[4-(Benzyloxy)-2,5-difluorophenyl]boronic Acid; 1452574-01-4; 2,5-Difluoro-4-benzyloxybenzeneboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Benzyloxyphenylboronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.