Description

Boc-Dl-Thyronine is a protected derivative of the thyroid hormone thyronine, where the tert-butoxycarbonyl (Boc) group serves as a critical amine-protecting moiety. This compound is essential for advanced pharmaceutical research and development, particularly in the synthesis of peptide-based drug candidates and hormone analogs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on endocrinology and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel thyroid hormone receptor agonists and antagonists.
• Peptide Chemistry Research: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: Serves as a precursor for creating hormone-protein conjugates for diagnostic assay development.
• Metabolic Pathway Studies: Employed in biochemical research to study hormone signaling and metabolic regulation.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical manufacturing.
• Prodrug Development: Utilized in designing prodrugs with improved stability and bioavailability profiles.

Basic Information

Product Name	Boc-Dl-Thyronine
CAS No.	1452572-11-0
Molecular Formula	C18H20INO6
Molecular Weight	473.26 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,5-diiodo-DL-thyronine; Boc-3,5-Diiodo-DL-thyronine; tert-Butyl (3,5-diiodo-4-(4-hydroxyphenoxy)phenyl)carbamate; DL-Thyronine, N-Boc-3,5-diiodo-; Boc-DL-T2; N-Boc-3,5-Diiodothyronine
EINECS	Contact for details

Quality Control

Our Boc-Dl-Thyronine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with research and development-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.