Description

4-Hydroxymethyl-2,6-Difluorophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a hydroxymethyl group and fluorine substituents, makes it an essential reagent for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a handle for bioconjugation and the development of chemical probes and inhibitors targeting specific enzymes.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligands for transition metal catalysts used in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within academic and CRO laboratories.

Basic Information

Product Name	4-Hydroxymethyl-2,6-Difluorophenylboronic Acid
CAS No.	1451393-60-4
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(4-(Hydroxymethyl)-2,6-difluorophenyl)boronic acid; 2,6-Difluoro-4-(hydroxymethyl)benzeneboronic acid; 4-(Hydroxymethyl)-2,6-difluorobenzeneboronic acid; B-[4-(Hydroxymethyl)-2,6-difluorophenyl]boronic acid; 4-Hydroxymethyl-2,6-difluorobenzeneboronic acid; 2,6-Difluoro-4-(hydroxymethyl)phenylboronic acid; 4-(Hydroxymethyl)-2,6-difluorophenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 4-Hydroxymethyl-2,6-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.