Description

3-Hydroxymethyl-4-(Trifluoromethoxy)Phenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring both a hydroxymethyl and a trifluoromethoxy substituent, makes it a valuable precursor for constructing complex molecules with enhanced physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy pharmacophore for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the boronic acid group enables efficient carbon-carbon bond formation.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential reagent in palladium-catalyzed cross-coupling reactions to create biaryl and heterobiaryl structures central to many drug discovery projects.
• Medicinal Chemistry & Drug Discovery: Employed in high-throughput screening and the synthesis of targeted compound libraries for hit identification and lead optimization.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Hydroxymethyl-4-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1451393-59-1
Molecular Formula	C8H8BF3O4
Molecular Weight	235.96 g/mol
Synonyms	[3-(Hydroxymethyl)-4-(trifluoromethoxy)phenyl]boronic acid; (3-Hydroxymethyl-4-trifluoromethoxyphenyl)boronic Acid; 4-Trifluoromethoxy-3-hydroxymethylbenzeneboronic Acid; 3-(Hydroxymethyl)-4-(trifluoromethoxy)benzeneboronic Acid; Boronic acid, B-[3-(hydroxymethyl)-4-(trifluoromethoxy)phenyl]-; 1451393-59-1
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-4-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.