Description

3,5-Bis(Trifluoromethyl)Benzylboronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through robust cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, especially those requiring the lipophilic, electron-withdrawing trifluoromethyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the benzylboronic acid moiety facilitates the introduction of the 3,5-bis(trifluoromethyl)benzyl group.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components, where fluorinated aromatic systems are desirable.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura couplings to form new carbon-carbon bonds, enabling the modular assembly of biaryl and other complex structures.
• Chemical Biology Probes: Useful for creating tagged molecules or affinity probes for studying biological systems and target engagement.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzylboronic Acid
CAS No.	1451393-52-4
Molecular Formula	C10H7BF6O2
Molecular Weight	284.97 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]methaneboronic Acid; (3,5-Bis(trifluoromethyl)benzyl)boronic Acid; 3,5-Bis(trifluoromethyl)benzenemethaneboronic Acid; α-Borono-3,5-bis(trifluoromethyl)toluene; Boronic acid, B-[3,5-bis(trifluoromethyl)phenyl]methyl-; 3,5-Di(trifluoromethyl)benzylboronic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 19F), HPLC, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for research and cGMP-compliant development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.