Description

2-Bromo-3-Trifluoromethylphenylboronic Acid CAS NO 1451393-48-8 is a high-value organoboron building block characterized by its bromine and trifluoromethyl substituents, which are critical for modulating electronic and steric properties in target molecules. This compound is essential for facilitating efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex, fluorinated intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced active ingredients for herbicides and pesticides, leveraging the unique properties of fluorine to improve efficacy and environmental profile.
• Material Science Research: Serves as a building block for developing specialty polymers, liquid crystals, and organic electronic materials that require specific halogenated and fluorinated aromatic units.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-3-Trifluoromethylphenylboronic Acid
CAS No.	1451393-48-8
Molecular Formula	C7H5BBrF3O2
Molecular Weight	268.83 g/mol
Synonyms	(2-Bromo-3-(trifluoromethyl)phenyl)boronic Acid; 2-Bromo-3-(trifluoromethyl)benzeneboronic Acid; B-(2-Bromo-3-(trifluoromethyl)phenyl)boronic Acid; 2-Bromo-alpha,alpha,α-trifluoro-m-tolylboronic Acid; Boronic acid, B-[2-bromo-3-(trifluoromethyl)phenyl]-; 1451393-48-8; 2-Bromo-3-trifluoromethylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-3-Trifluoromethylphenylboronic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure consistency and reliability. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP (current Good Manufacturing Practice) standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.