Description

4-Chloro-2-Fluoro-3-Formylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a halogenated aromatic ring, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients through efficient cross-coupling and subsequent functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl compounds, which are core structures in many drug candidates targeting various diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogen and formyl groups for further chemical modifications.
• Material Science Research: Serves as a monomer or linker for constructing novel organic frameworks, polymers, and liquid crystals with specific electronic or structural properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and sensors due to the reactivity of the boronic acid group with diols and the formyl group for conjugation.
• Catalyst Ligand Development: The boronic acid functionality can be used to create sophisticated ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Item	Detail
Product Name	4-Chloro-2-Fluoro-3-Formylphenylboronic Acid
CAS No.	1451393-44-4
Molecular Formula	C7H5BClFO3
Molecular Weight	201.38 g/mol
Synonyms	(4-Chloro-2-fluoro-3-formylphenyl)boronic acid; 3-Borono-4-chloro-2-fluorobenzaldehyde; 4-Chloro-2-fluoro-3-formylbenzeneboronic acid; 2-Fluoro-4-chloro-3-formylphenylboronic acid; Boronic acid, B-(4-chloro-2-fluoro-3-formylphenyl)-; 1451393-44-4; 4-Chloro-2-fluoro-3-carboxaldehydephenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluoro-3-Formylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.