Description

3-Formyl-5-(Trifluoromethoxy)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative featuring both an aldehyde and a trifluoromethoxy substituent on the aromatic ring. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile building block for modern organic synthesis, particularly in cross-coupling reactions. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing complex biaryl structures prevalent in drug discovery and material science.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: The boronic acid and aldehyde functionalities allow it to be incorporated into novel ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors, due to its electron-withdrawing substituents.
• Chemical Biology Probes: Useful for synthesizing probes and sensors that leverage boronic acid's affinity for diols, combined with the reactive aldehyde handle for bioconjugation.

Basic Information

Product Name	3-Formyl-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1451393-39-7
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	5-(Trifluoromethoxy)-3-formylbenzeneboronic acid; 3-Formyl-5-(trifluoromethoxy)benzeneboronic acid; [3-Formyl-5-(trifluoromethoxy)phenyl]boronic acid; 3-Borono-5-(trifluoromethoxy)benzaldehyde; (3-Formyl-5-(trifluoromethoxyl)phenyl)boronic acid; Boronic acid, B-[3-formyl-5-(trifluoromethoxy)phenyl]-; CAS 1451393-39-7
EINECS	Contact for details

Quality Control

Every batch of 3-Formyl-5-(Trifluoromethoxy)Phenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.