Description

3,4-Difluoro-5-Formylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a difluorinated aromatic ring, makes it an exceptionally versatile reagent for cross-coupling reactions and subsequent functionalization. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in novel drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for conjugated polymers.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the creation of fluorescent or affinity probes due to its reactive aldehyde and boronic acid groups.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis organizations (CSOs) and CDMOs producing tailored compounds for client projects.

Basic Information

Product Name	3,4-Difluoro-5-Formylphenylboronic Acid
CAS No.	1451393-34-2
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(3,4-Difluoro-5-formylphenyl)boronic acid; 5-Borono-2,3-difluorobenzaldehyde; 2,3-Difluoro-5-formylbenzeneboronic acid; 3,4-Difluoro-5-carboxaldehydephenylboronic acid; Boronic acid, B-(3,4-difluoro-5-formylphenyl)-; 1451393-34-2; 3,4-Difluoro-5-formylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Formylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.