Description

3-(3-Bromophenylcarbamoyl)-4-Fluorophenylboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic synthesis for constructing complex biaryl structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those containing complex biaryl motifs for oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific halogenated and fluorinated aromatic structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its boronic acid functionality.
• Chemical Research: An essential reagent in academic and industrial R&D labs for methodological studies in palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Development: Can be utilized to synthesize novel bidentate ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API (Active Pharmaceutical Ingredient) batches.

Basic Information

Product Name	3-(3-Bromophenylcarbamoyl)-4-Fluorophenylboronic Acid
CAS No.	1451393-30-8
Molecular Formula	C13H10BBrFNO3
Molecular Weight	338.94 g/mol
Synonyms	4-Fluoro-3-[(3-bromophenyl)carbamoyl]phenylboronic Acid; [4-Fluoro-3-[(3-bromophenyl)aminocarbonyl]phenyl]boronic Acid; 3-Carbamoyl-4-fluorophenylboronic Acid, 3-Bromo Derivative; B-[4-Fluoro-3-[[(3-bromophenyl)amino]carbonyl]phenyl]boronic Acid; (3-((3-Bromophenyl)carbamoyl)-4-fluorophenyl)boronic Acid; Boronic acid, B-[4-fluoro-3-[[(3-bromophenyl)amino]carbonyl]phenyl]-; 1451393-30-8
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Bromophenylcarbamoyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.