Description

3-(3-Chloro-4-Fluorophenylcarbamoyl)-4-Fluorophenylboronic Acid is a sophisticated boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its primary value lies in its role as a versatile building block for constructing complex molecules via cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly those requiring specific fluorinated and chlorinated aromatic scaffolds. Its precise structure enables the targeted synthesis of novel compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorinated phenyl groups can enhance bioavailability and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: A versatile reagent for Suzuki-Miyaura cross-coupling reactions to form biaryl and heterobiaryl structures, which are common motifs in many functional molecules.
• Discovery Chemistry: Employed in medicinal chemistry and high-throughput screening for constructing diverse compound libraries to identify new lead structures.

Basic Information

Product Name	3-(3-Chloro-4-Fluorophenylcarbamoyl)-4-Fluorophenylboronic Acid
CAS No.	1451393-29-5
Molecular Formula	C13H9BClF2NO3
Molecular Weight	311.48 g/mol
Synonyms	4-Fluoro-3-[[(3-chloro-4-fluorophenyl)amino]carbonyl]benzeneboronic Acid; [4-Fluoro-3-[(3-chloro-4-fluoroanilino)carbonyl]phenyl]boronic Acid; 3-Carbamoyl-4-fluorophenylboronic Acid derivative; Boronic acid, B-[4-fluoro-3-[[(3-chloro-4-fluorophenyl)amino]carbonyl]phenyl]-; (3-((3-Chloro-4-fluorophenyl)carbamoyl)-4-fluorophenyl)boronic Acid
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-4-Fluorophenylcarbamoyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.