Description

5-Bromo-3-Chloro-2-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its unique halogen substitution pattern, which enables precise cross-coupling reactions for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with specific halogenated aromatic cores for enhanced efficacy.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organometallic complexes.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for proteomics, biomarker discovery, and diagnostic assay development.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	5-Bromo-3-Chloro-2-Fluorophenylboronic Acid
CAS No.	1451393-27-3
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(5-Bromo-3-chloro-2-fluorophenyl)boronic acid; 2-Fluoro-5-bromo-3-chlorophenylboronic acid; 5-Bromo-3-chloro-2-fluorobenzeneboronic acid; Boronic acid, B-(5-bromo-3-chloro-2-fluorophenyl)-; 1451393-27-3; 3-Chloro-5-bromo-2-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.