Description

3,5-Bis(Trifluoromethyl)-2-Bromophenylboronic Acid is a highly functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of electron-withdrawing trifluoromethyl groups and a reactive boronic acid handle, enabling precise cross-coupling reactions to construct complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced materials where fluorinated motifs are required to modulate properties like metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing trifluoromethylated biaryl scaffolds.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Building block for organic electronic materials, such as OLEDs and semiconductors, where fluorinated units improve charge transport and stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and studying biological systems.
• Custom Synthesis and Contract Manufacturing: A high-value starting material for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)-2-Bromophenylboronic Acid
CAS No.	1451393-23-9
Molecular Formula	C9H4BBrF6O2
Molecular Weight	324.84 g/mol
Synonyms	[2-Bromo-3,5-bis(trifluoromethyl)phenyl]boronic acid; 2-Bromo-3,5-bis(trifluoromethyl)benzeneboronic acid; 3,5-Bis(trifluoromethyl)-2-bromobenzeneboronic acid; Boronic acid, B-[2-bromo-3,5-bis(trifluoromethyl)phenyl]-; 2-Bromo-α,α,α,α',α',α'-hexafluoro-m-xylene-5-boronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)-2-Bromophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.