Description

3-Carboxy-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a carboxylic acid and a boronic acid group on a trifluoromethylated aromatic ring, makes it an indispensable reagent for constructing complex molecules. This compound is primarily sought after by research scientists and process chemists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling and other advanced synthesis routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl moiety often contributes to improved efficacy.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic acid coupling partner for forming carbon-carbon bonds, essential for creating biaryl structures in drug discovery and material science.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of advanced organic frameworks, polymers, and electronic materials with specific functional properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	3-Carboxy-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1451393-22-8
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	5-Carboxy-3-(Trifluoromethyl)benzeneboronic Acid; [3-(Trifluoromethyl)-5-carboxyphenyl]boronic Acid; 3-Borono-5-(trifluoromethyl)benzoic Acid; 3-Carboxy-5-trifluoromethylphenylboronic Acid; 5-Borono-3-(trifluoromethyl)benzoic Acid; m-Carboxy-m-trifluoromethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Carboxy-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for research and commercial synthesis. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity, identity, and impurity profiles. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.