Description

4-Bromo-2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for enhanced biological activity and stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where its specific halogen and boron functionality allows for fine-tuning of electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex fragments in multi-step synthesis projects.

Basic Information

Product Name	4-Bromo-2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1451393-21-7
Molecular Formula	C7H4BBrClF3O2
Molecular Weight	303.27 g/mol
Synonyms	[4-Bromo-2-chloro-5-(trifluoromethyl)phenyl]boronic acid; 2-Chloro-4-bromo-5-(trifluoromethyl)benzeneboronic acid; (4-Bromo-2-chloro-5-(trifluoromethyl)phenyl)boronic acid; 4-Bromo-2-chloro-alpha,alpha,α-trifluoro-m-tolylboronic acid; Boronic acid, B-[4-bromo-2-chloro-5-(trifluoromethyl)phenyl]-; 1451393-21-7; 4-Br-2-Cl-5-CF3-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical testing including NMR, HPLC, and elemental analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.