Description

2,3-Difluoro-6-Benzyloxyphenylboronic Acid is a high-purity, synthetically valuable boronic acid derivative. This compound serves as a critical building block in modern organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require precise fluorinated intermediates for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex, fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the difluoro and benzyloxy motifs can enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Suzuki-Miyaura Cross-Coupling: Primarily utilized as a versatile boronic acid partner for forming carbon-carbon bonds with aryl halides, enabling the construction of complex biaryl systems.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful in constructing molecular probes and tags for studying biological processes due to its reactive boronic acid group.

Basic Information

Product Name	2,3-Difluoro-6-Benzyloxyphenylboronic Acid
CAS No.	1451393-19-3
Molecular Formula	C₁₃H₁₁BF₂O₃
Molecular Weight	264.03 g/mol
Synonyms	(2,3-Difluoro-6-(benzyloxy)phenyl)boronic acid; 2,3-Difluoro-6-(phenylmethoxy)benzeneboronic acid; 2-(Benzyloxy)-3,4-difluorophenylboronic acid; B-(2,3-Difluoro-6-benzyloxyphenyl)boronic acid; 1451393-19-3; 2,3-Difluoro-6-benzyloxybenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-Benzyloxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.