Description

2-Bromo-6-(Trifluoromethoxy)Phenyboronic Acid is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures containing the 2-bromo-6-(trifluoromethoxy)phenyl moiety.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a halogenated, trifluoromethoxy-substituted aromatic core.
• Agrochemical Research: Used in constructing novel herbicide and pesticide candidates, leveraging the bioactivity often associated with the trifluoromethoxy group.
• Material Science: Serves as a precursor in the development of advanced organic electronic materials, such as OLEDs and semiconductors.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	2-Bromo-6-(Trifluoromethoxy)Phenyboronic Acid
CAS No.	1451393-18-2
Molecular Formula	C7H5BBrF3O3
Molecular Weight	283.83 g/mol
Synonyms	[2-Bromo-6-(trifluoromethoxy)phenyl]boronic acid; (2-Bromo-6-(trifluoromethoxy)phenyl)boronic acid; 2-Bromo-6-(trifluoromethoxy)benzeneboronic acid; B-[2-Bromo-6-(trifluoromethoxy)phenyl]boronic acid; 2-Bromo-6-trifluoromethoxyphenylboronic acid; Boronic acid, B-[2-bromo-6-(trifluoromethoxy)phenyl]-; 1451393-18-2
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Trifluoromethoxy)Phenyboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.