Description

3-Benzyloxy-4-Bromo-2,6-Difluorophenylboronic Acid is a high-value, multi-functional boronic acid derivative used as a key synthetic intermediate. Its molecular structure, featuring bromo, fluoro, and benzyloxy substituents, makes it a versatile building block for constructing complex molecules via cross-coupling reactions. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides by introducing the difluorophenyl moiety into target molecules.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its aromatic and halogenated structure is beneficial.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key building block for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	3-Benzyloxy-4-Bromo-2,6-Difluorophenylboronic Acid
CAS No.	1451393-14-8
Molecular Formula	C13H10BBrF2O3
Molecular Weight	342.93 g/mol
Synonyms	(3-(Benzyloxy)-4-bromo-2,6-difluorophenyl)boronic acid; 4-Bromo-3-(phenylmethoxy)-2,6-difluorobenzeneboronic acid; Boronic acid, B-[3-(benzyloxy)-4-bromo-2,6-difluorophenyl]-; 3-Benzyloxy-4-bromo-2,6-difluorobenzeneboronic acid; 2,6-Difluoro-3-benzyloxy-4-bromophenylboronic acid; 1451393-14-8; B-[3-(Benzyloxy)-4-bromo-2,6-difluorophenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 3-Benzyloxy-4-Bromo-2,6-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.