Description

4-Chloro-2-Fluoro-3-Hydroxyphenylboronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules via cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A fundamental reagent in medicinal chemistry and process chemistry for constructing complex, fluorinated and chlorinated aromatic scaffolds.
• Ligand Synthesis: Used to prepare sophisticated boronic acid-based ligands for catalysis and molecular recognition applications.
• Diagnostic Reagents: Potential use in the development of sensors and assay components due to its specific binding properties.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Hydroxyphenylboronic Acid
CAS No.	1451393-13-7
Molecular Formula	C6H5BClFO3
Molecular Weight	189.37 g/mol
Synonyms	(4-Chloro-2-fluoro-3-hydroxyphenyl)boronic acid; 3-Borono-4-chloro-2-fluorophenol; 4-Chloro-2-fluoro-3-hydroxybenzeneboronic acid; 2-Fluoro-4-chloro-3-hydroxybenzeneboronic acid; Boronic acid, B-(4-chloro-2-fluoro-3-hydroxyphenyl)-; CAS 1451393-13-7
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.