Description

2,4-Difluoro-3-Iodophenylboronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecules with specific halogen and fluorine substitution patterns. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules. Its unique halogenated structure makes it a key intermediate for creating compounds with tailored biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the difluoro and iodo substituents confer specific biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, via polymerization or functionalization.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes, leveraging the iodine atom for further radiolabeling or bioconjugation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	2,4-Difluoro-3-Iodophenylboronic Acid
CAS No.	1451393-12-6
Molecular Formula	C6H4BClF2IO2
Molecular Weight	299.26 g/mol
Synonyms	(2,4-Difluoro-3-iodophenyl)boronic acid; 3-Iodo-2,4-difluorophenylboronic acid; Boronic acid, B-(2,4-difluoro-3-iodophenyl)-; 2,4-Difluoro-3-iodobenzeneboronic acid; 1451393-12-6; AKOS040759623; FT-0776937
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-3-Iodophenylboronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. Our quality commitment includes comprehensive analysis via HPLC, NMR, and mass spectrometry to verify identity, purity, and the absence of critical metallic impurities (e.g., Pd) that can poison catalysts. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to prevent decomposition. Keep the container sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.