Description

3-Carboxy-4-Chloro-2-Fluorophenylboronic Acid is a high-purity, multi-functional boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its value lies in its unique molecular structure, which incorporates halogen and carboxylic acid functional groups, enabling precise cross-coupling reactions and molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its halogenated aromatic structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in creating specialty polymers and organic electronic materials.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and sensors.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the scalable production of complex, bespoke organic molecules for client projects.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	3-Carboxy-4-Chloro-2-Fluorophenylboronic Acid
CAS No.	1451393-04-6
Molecular Formula	C7H5BClFO4
Molecular Weight	217.38 g/mol
Synonyms	(3-Carboxy-4-chloro-2-fluorophenyl)boronic acid; 4-Chloro-2-fluoro-3-boronobenzoic acid; 2-Fluoro-4-chloro-3-carboxyphenylboronic acid; Boronic acid, B-(3-carboxy-4-chloro-2-fluorophenyl)-; 1451393-04-6; 3-Borono-4-chloro-2-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our 3-Carboxy-4-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP and ISO guidelines for consistent, reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.