Description

2-Formyl-6-(Trifluoromethyl)Phenylboronic Acid is a specialized bifunctional boronic acid derivative that serves as a key building block in modern synthetic chemistry. Its unique structure, combining a formyl group and a boronic acid moiety on a trifluoromethyl-substituted aromatic ring, makes it a versatile precursor for constructing complex molecular architectures. This high-value intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials. Its precise functionalization enables efficient cross-coupling and subsequent transformations critical for drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those incorporating trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl and boronic acid functionalities contribute to target specificity and efficacy.
• Material Science: Serves as a monomer or linker in the synthesis of organic frameworks, polymers, and liquid crystals with tailored electronic or optical properties.
• Chemical Synthesis: Employed as a versatile reagent for the sequential functionalization of aromatic systems, enabling the rapid generation of compound libraries for screening.
• Diagnostic Probe Development: Utilized in creating molecular probes and sensors that leverage boronic acid's affinity for diols, combined with the spectroscopic handle provided by the formyl group.

Basic Information

Product Name	2-Formyl-6-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1451392-93-0
Molecular Formula	C8H6BF3O3
Molecular Weight	217.94 g/mol
Synonyms	6-Formyl-2-(trifluoromethyl)benzeneboronic acid; 2-(Trifluoromethyl)-6-formylphenylboronic acid; [2-Formyl-6-(trifluoromethyl)phenyl]boronic acid; 2-Carboxy-3-(trifluoromethyl)benzeneboronic acid (tautomer); Boronic acid, B-[2-formyl-6-(trifluoromethyl)phenyl]-; 1451392-93-0; (2-Formyl-6-(trifluoromethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2-Formyl-6-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis using techniques including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.