Description

2-Formyl-3-(trifluoromethoxy)phenylboronic acid is a high-value, multifunctional boronic acid derivative featuring both a formyl group and a trifluoromethoxy substituent on the aromatic ring. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile building block for modern synthetic chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules, particularly in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring the trifluoromethoxy pharmacophore.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds to create biaryl structures in complex organic synthesis.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Material Science: Building block for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and sensors for biochemical research.

Basic Information

Product Name	2-Formyl-3-(trifluoromethoxy)phenylboronic Acid
CAS No.	1451392-92-9
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	[2-Formyl-3-(trifluoromethoxy)phenyl]boronic acid; 2-Formyl-3-(trifluoromethoxy)benzeneboronic acid; 3-Formyl-2-(trifluoromethoxy)phenylboronic acid; Boronic acid, B-[2-formyl-3-(trifluoromethoxy)phenyl]-; 2-(Trifluoromethoxy)benzaldehyde-3-boronic acid; CAS 1451392-92-9
EINECS	Contact for details

Quality Control

Our 2-Formyl-3-(trifluoromethoxy)phenylboronic acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.