Description

3,4-Difluoro-2-Formylphenylboronic Acid CAS NO 1451392-91-8 is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a difluorinated aromatic ring, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or linker in the development of advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the creation of novel bidentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme activity and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3,4-Difluoro-2-Formylphenylboronic Acid
CAS No.	1451392-91-8
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(3,4-Difluoro-2-formylphenyl)boronic acid; 2-Borono-3,4-difluorobenzaldehyde; 3,4-Difluoro-2-formylbenzeneboronic acid; 3,4-Difluorosalicylaldehyde boronic acid; DFBA (abbrev.); B-(3,4-Difluoro-2-formylphenyl)boronic acid; 2-Formyl-3,4-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-2-Formylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO compliant workflows for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.